FOR RESEARCHERS & CLINICIANS
Help turn pathway convergence into testable translational programs.
We are seeking expertise in Rho-family signaling, actin biology, rare NDDs, disease modeling, pharmacology, biomarkers, pediatric safety, and regulatory science.
Mechanism
Evaluate pathway direction, cell-type relevance, developmental timing, and the strength of causal evidence.
Models and assays
Develop or apply disease models and harmonized assays for target engagement and phenotypic rescue.
Translation
Design safety, pharmacology, biomarker, natural-history, and early clinical-development strategies.
Ways to contribute
- Serve on the scientific working group
- Review a disease-mechanism dossier
- Share an existing model or assay
- Advise on ROCK1 versus ROCK2 selectivity
- Develop target-engagement biomarkers
- Participate in protocol or regulatory planning