Not medical advice

This website is for educational and collaborative planning purposes only. It does not provide medical advice, recommend treatment, or replace consultation with a qualified clinician.

No claim of safety or efficacy

ROCK inhibitors, including fasudil, have not been established as safe or effective for OPHN1-related disorder or other rare genetic neurodevelopmental disorders described on this site. Any use must occur under applicable clinical, ethical, and regulatory oversight.

Evidence changes

The science is evolving. Pathway relationships may be incomplete, context-dependent, or contradicted by future evidence.

Conflicts and funding

Financial support, industry relationships, intellectual property interests, and relevant conflicts should be disclosed for projects and participants as the collaborative develops.